|
KMID : 0438219730100020601
|
|
Korea University Medical Journal
1973 Volume.10 No. 2 p.601 ~ p.607
|
|
|
Simplified Method for the preparation of Indium-113m Liver Scanning Compound
|
|
|
|
|
Abstract
|
|
|
Liver and spleen scanning to be reported presently have several methods of Indium chloride; method with citric acid, with sodium phosphate buffer, with citric acid & ferric chloride, with phosphate buffer and PVP, with gelatin and phosphate buffer, with gelatin and phosphate buffer including ferric chloride, with ferric chloride and gelatin. All foregoing methods is relatively caused some decreased activity, side reaction occasionally by complicate procedure and unnecessary consumption of time.
As this simple manner with gelatin and phosphate buffer in our laboratory compare with above methods.
Following results were obtained;
1. Indium-chloride is prepared in following manner;
Ⅰ. Ten ml. of phosphate buffer is added directly to 200mg. of high grade gelatin, and then this mixture is autoclaved for 20 minutes at a pressure of 15 PSI.
Ⅱ. A commecially available Sn-113 In-113m generator (Abbott Co.) is eluted with 3 to 6 ml. of 0.05N HCI, after removing 0.6-1.0ml. dead volume.
2. The pharmacologic manipulation of this pre-paeparation method is so simple that it may be performed without difficulty equipment or additional high trained personal.
3. This modified pre-preparation method is much simpler and can be promptly processed than any other previous method. Shortening of handling time offers another advantage of reducing exposure to the technical personal.
4. High specific activity of Indium-113m can be obtained with preparation of smaller volume of the eluted solution by removing dead volume.
5. Our present method has advantages of not only little side reaction but more simplicity while other reporters have complicate procedures and seldom side reaction
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|